Porous SiO2 -coated ultrasmall selenium particles nanospheres attenuate cerulein-induce acute pancreatitis in mice by downregulating oxidative stress.
Jun Jie FanQi Xiang MeiGuo Ying DengZe Hua HuangYang FuJun Hui HuChun Lan HuangYing Ying LuLun Gen LuXing Peng WangYue ZengPublished in: Journal of digestive diseases (2021)
Se@SiO2 nanospheres may alleviate AP by relieving oxidative stress and targeting the TLR4/Myd88/p-p65 and NQO1/Nrf2/HO-1 pathways.
Keyphrases
- oxidative stress
- toll like receptor
- diabetic rats
- ischemia reperfusion injury
- dna damage
- induced apoptosis
- inflammatory response
- transcription factor
- immune response
- high fat diet induced
- magnetic nanoparticles
- nuclear factor
- metabolic syndrome
- cell proliferation
- type diabetes
- pi k akt
- heat shock
- signaling pathway
- endoplasmic reticulum stress
- highly efficient
- adipose tissue
- wild type
- tissue engineering
- iron oxide