Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival.

Dawei LiGuimei TianJia WangLisa Y ZhaoOlivia CoZoe C UnderillJoe S MymrykFrank ClaessensScott M DehmYehia DaakaDaiqing Liao

Published in: The Prostate (2018)

Ad12 E1A inhibits AR-mediated transcription and suppresses PCa cell survival, suggesting that targeting the AR by E1A12 might have therapeutic potential for treating advanced PCa with heightened AR signaling.

Keyphrases

prostate cancer
radical prostatectomy
signaling pathway
transcription factor
cancer therapy
drug delivery
gene therapy