Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures.

Umair Mahmood Andrew Blake Sanjay Rathee Leslie M Samuel Graeme I Murray David Sebag-Montefiore Simon Gollins Nicholas P West Rubina Begum Simon P Bach Susan D Richman Philip Quirke Keara L Redmond Manuel Salto Tellez Viktor Hendrik Koelzer Simon J Leedham Ian P M Tomlinson Philip David Dunne Francesca M Buffanull nullTimothy S Maughan Enric Domingo

Published in: Cancer research communications (2024)

Rectal cancers with stromal features may respond better to RT and 5FU/Cap with the addition of Ox. Within patients not treated with Ox, high levels of cytotoxic lymphocytes associate with response only in immune and stromal tumors. Our analyses provide biological insights about the outcome by different radiotherapy regimens in rectal cancer.

Keyphrases

rectal cancer
locally advanced
newly diagnosed
end stage renal disease
early stage

bone marrow
radiation therapy
squamous cell carcinoma
gene expression
transcription factor

peritoneal dialysis
peripheral blood
lymph node
patient reported outcomes

young adults
patient reported
heat shock protein
heat shock