Nuclear lncRNA NORSF reduces E2 release in granulosa cells by sponging the endogenous small activating RNA miR-339.
Miaomiao WangYang WangLiu YangXing DuQifa LiPublished in: BMC biology (2023)
Our findings highlight an unappreciated mechanism of nuclear lncRNAs and show it acts as a ceRNA, which may be a common lncRNA function in the cytoplasm and nucleus. We also identified a potential endogenous saRNA for improving female fertility and treating female infertility.
Keyphrases
- long non coding rna
- long noncoding rna
- induced apoptosis
- polycystic ovary syndrome
- cell cycle arrest
- signaling pathway
- cell proliferation
- endoplasmic reticulum stress
- cell death
- type diabetes
- insulin resistance
- climate change
- risk assessment
- skeletal muscle
- childhood cancer
- adipose tissue
- transcription factor
- pi k akt
- nucleic acid