Genome-wide computational analysis of potential long noncoding RNA mediated DNA:DNA:RNA triplexes in the human genome.

Saakshi JalaliAmrita SinghSouvik MaitiVinod Scaria

Published in: Journal of translational medicine (2017)

Our analysis shows that PTS are enriched in gene promoter and largely associated with simple repeats. The current study suggests a major role of a subset of lncRNAs in mediating chromatin organization modulation through CTCF and NSRF proteins.

Keyphrases

genome wide
long noncoding rna
dna methylation
circulating tumor
copy number
cell free
endothelial cells
single molecule
transcription factor
nucleic acid
gene expression
genome wide identification
dna damage
induced pluripotent stem cells
risk assessment
circulating tumor cells
network analysis