Glycaemic Imbalances in Seizures and Epilepsy of Paediatric Age: A Literature Review.
Emanuele BartoliniAnna Rita FerrariSimona FioriStefania Della VecchiaPublished in: Journal of clinical medicine (2023)
Cerebral excitability and systemic metabolic balance are closely interconnected. Energy supply to neurons depends critically on glucose, whose fluctuations can promote immediate hyperexcitability resulting in acute symptomatic seizures. On the other hand, chronic disorders of sugar metabolism (e.g., diabetes mellitus) are often associated with long-term epilepsy. In this paper, we aim to review the existing knowledge on the association between acute and chronic glycaemic imbalances (hyper- and hypoglycaemia) with seizures and epilepsy, especially in the developing brain, focusing on clinical and instrumental features in order to optimize the care of children and adolescents and prevent the development of chronic neurological conditions in young patients.
Keyphrases
- type diabetes
- drug induced
- healthcare
- liver failure
- temporal lobe epilepsy
- end stage renal disease
- respiratory failure
- newly diagnosed
- ejection fraction
- intensive care unit
- emergency department
- chronic kidney disease
- cerebral ischemia
- spinal cord
- aortic dissection
- white matter
- peritoneal dialysis
- adipose tissue
- case report
- subarachnoid hemorrhage
- pain management
- skeletal muscle
- chronic pain
- prognostic factors
- quality improvement
- working memory
- functional connectivity
- health insurance
- middle aged
- insulin resistance