Cerebral Amyloid Angiopathy Pathology and Its Association With Amyloid-β PET Signal.
Stuart J McCarterTimothy G LesnickVal LoweMichelle M MielkeEleni ConstantopoulosAlejandro A RabinsteinScott A PrzybelskiHugo BothaDavid T JonesVijay K RamananClifford R JackRonald C PetersenDavid KnopmanBradley F BoeveMelissa E MurrayGourisankar GhoshPrashanthi VemuriKejal KantarciRobert Ross ReichardJonathan Graff-RadfordPublished in: Neurology (2021)
We did not find evidence that pathologically confirmed regional CAA burden contributes significantly to proximal antemortem regional PiB-PET signal, suggesting that amyloid PET imaging for measurement of cortical amyloid burden is unconfounded by CAA on a lobar level. Whether CAA burden contributes to PiB-PET signal in patients with severe CAA phenotypes, such as lobar hemorrhage, requires further investigation.