Tracking cortical excitability dynamics with transcranial magnetic stimulation in focal epilepsy.
Robert M HellingSharon ShmuelyPrisca R BauerElse A TolnerGerhard H VisserRoland D ThijsPublished in: Annals of clinical and translational neurology (2022)
Serial within-subject rMT measurements yielded reproducible, stable results in healthy controls. ASM tapering and seizures had distinct effects on TMS-EMG excitability indices in people with epilepsy. Drug tapering decreased rMT, indicating increased overall corticospinal excitability, whereas seizures affected intracortical inhibition with contrasting effects between seizure types.