Perioperative replacement therapy in haemophilia B: An appeal to "B" more precise.
Hendrika C A M HazendonkT PreijersR LiesnerPratima ChowdaryD HartD KeelingM H E DriessensB A P Laros-van GorkomF J M van der MeerK MeijerK FijnvandraatFrank W G LeebeekR A A MathôtP W CollinsM H CnossenPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2018)
This study demonstrates that targeting of FIX levels in the perioperative setting is complex and suboptimal, but although this bleeding is minimal. Alternative dosing strategies taking patient and surgical characteristics as well as pharmacokinetic principles into account may help to optimize and individualize treatment.