Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma.

Soichiro NishiokaPing-Hsiu WuToshiaki YakabeAmato J GiacciaQuynh-Thu LeHidefumi AoyamaShinichi ShimizuHiroki ShiratoYasuhito OnoderaJin-Min Nam

Published in: Neuro-oncology advances (2020)

Our results show that Rab27b mediates the radioresistance of highly malignant GBM cells. Rab27b promotes the proliferation of adjacent cells through EREG-mediated paracrine signaling after irradiation. Thus, the Rab27b-EREG pathway is a novel potential target to improve the efficacy of radiotherapy in GBM.

Keyphrases

induced apoptosis
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
radiation induced
cell death
radiation therapy
oxidative stress
cell proliferation
squamous cell carcinoma
locally advanced
cancer stem cells
climate change
risk assessment
rectal cancer