Combined use of multiparametric flow cytometry and cytomorphology to enhance detection of neuroblastoma metastatic cells in bone marrow.
Christine ManenqJean-François LesesveNatacha DreumontFrédéric MassinSylvain SalignacLudovic MansuyPascal ChastagnerVéronique Latger-CannardJulien BroseusPublished in: International journal of laboratory hematology (2019)
These results illustrate the performance of multiparametric FC analysis to detect metastatic BM infiltration of NB. This is of particular interest in an emergency context, since when combined with light microscopy, it enhances the detection of metastatic invasion within a short timeframe, allowing an adapted and rapid clinical management.
Keyphrases
- loop mediated isothermal amplification
- flow cytometry
- squamous cell carcinoma
- small cell lung cancer
- bone marrow
- label free
- induced apoptosis
- public health
- mesenchymal stem cells
- healthcare
- single molecule
- cell cycle arrest
- sensitive detection
- high throughput
- optical coherence tomography
- signaling pathway
- high speed
- cell proliferation