The impact of skeletal muscle on the pharmacokinetics and toxicity of 5-fluorouracil in colorectal cancer.

Grant R WilliamsAllison M DealShlomit Strulov ShacharChristine M WalkoJai N PatelBert O'NeilHoward L McLeodMarc S WeinbergSeul Ki ChoiHyman B MussHanna K Sanoff

Published in: Cancer chemotherapy and pharmacology (2017)

Although our results did not confirm the impact of low skeletal muscle on PKs of 5FU, further research exploring the impact of body composition on chemotherapy PKs and related toxicities is warranted with the potential for alternative dosing strategies in sarcopenic patients to reduce unnecessary toxicities while maintaining efficacy.

Keyphrases

skeletal muscle
body composition
end stage renal disease
resistance training
insulin resistance
ejection fraction
newly diagnosed
bone mineral density
peritoneal dialysis
oxidative stress
prognostic factors
patient reported outcomes
locally advanced
climate change