Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/β2 -AR/MACC1 axis.

Changqie PanJianhua WuSiting ZhengHuiying SunYisheng FangZhenhua HuangMin ShiLi LiangJianping BinYulin LiaoJinzhang ChenWang-Jun Liao

Published in: Cancer communications (London, England) (2021)

Catecholamine-induced neuroendocrine phenotypes of GC cells led to depression-accelerated GC invasion and metastasis via the β2 -AR/MACC1 axis, while β2 -AR antagonist or MACC1 silencing could reverse it, showing promising potential therapeutic strategies for improving the outcome of GC patients with comorbid depression.

Keyphrases

depressive symptoms
sleep quality
cell migration
induced apoptosis
gas chromatography
high glucose
cell cycle arrest
signaling pathway
mass spectrometry
drug induced
climate change
human health
simultaneous determination