Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness.
Yollanda E M FrancoMaria Jose AlvesMiyuki UnoIsabele Fattori MorettiMarina Trombetta-LimaSuzana de Siqueira SantosAncely Ferreira Dos SantosGabriel Santos AriniMauricio S BaptistaAntonio Marcondes LerarioSueli Mieko Oba-ShinjoSuely Kazue Nagahashi MariePublished in: Cancer & metabolism (2021)
In glioblastoma, particularly in the mesenchymal subtype, the downregulation of both genes and proteins (GLUD1 and GPT2) increases the source of glutamate for GSH synthesis and enhances tumor cell fitness due to increased antioxidative capacity. In contrast, in lower-grade astrocytoma, mainly in those harboring the IDH1 mutation, the gene expression profile indicates that tumor cells might be sensitized to oxidative stress due to reduced GSH synthesis. The measurement of GLUD1 and GPT2 metabolic substrates, ammonia, and alanine, by noninvasive MR spectroscopy, may potentially allow the identification of IDH1mut AGII and AGIII progression towards secondary GBM.
Keyphrases
- oxidative stress
- genome wide
- magnetic resonance
- low grade
- stem cells
- bioinformatics analysis
- bone marrow
- genome wide identification
- contrast enhanced
- physical activity
- single cell
- cell proliferation
- dna damage
- body composition
- copy number
- single molecule
- magnetic resonance imaging
- dna methylation
- anaerobic digestion
- mesenchymal stem cells
- gene expression
- computed tomography
- diabetic rats
- endoplasmic reticulum stress
- solid state