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Fluoroalkyl sulfides as photoredox-active coupling reagents for alkene difunctionalization.

Mikhail D KosobokovMikhail O ZubkovVitalij V LevinVladimir A KokorekinAlexander D Dilman
Published in: Chemical communications (Cambridge, England) (2021)
A visible-light-promoted fluoroalkylation-thiolation of alkenes is described. A 4-tetrafluoropyridinylthio fragment serves as a photoredox-active group in the initiation step and undergoes a radical group transfer, which is important for the reaction efficiency. In the primary products, the pyridinylthio substituent may be further functionalized via radical processes or an aromatic substitution reaction.
Keyphrases
  • visible light
  • electron transfer
  • quantum dots
  • room temperature
  • molecularly imprinted
  • mass spectrometry
  • liquid chromatography