Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects.
Iñaki Robles-VeraMarta ToralNéstor de la VisitaciónManuel SánchezManuel Gómez-GuzmánRaquel MuñozFrancesca AlgieriTeresa VezzaRosario JimenezJulio GálvezMiguel RomeroJuan Miguel RedondoJuan DuartePublished in: British journal of pharmacology (2020)
In SHR, losartan treatment reduced gut dysbiosis and sympathetic drive in the gut, thus improving gut integrity. The changes induced by losartan in gut microbiota contributed, in part, to protecting the vasculature and reducing BP, possibly by modulating the immune system in the gut.