Reducing kidney uptake of radiolabelled exendin-4 using variants of the renally cleavable linker MVK.

Belinda TrachselGiulia ValpredaAlexandra LutzRoger SchibliLinjing MuMartin P Béhé

Published in: EJNMMI radiopharmacy and chemistry (2023)

Cleavable linkers are highly efficient in reducing the radioactivity burden in the kidney. Though the dual linker approach using the instillation of MV-MVK or MVK-MVK between exendin-4 and the radiometal chelator did not significantly outperform the single cleavable linker MVK, further structural optimization or the combination of different cleavable linkers could be a stepping stone in reducing radiation-induced nephrotoxicity.

Keyphrases

radiation induced
highly efficient
radiation therapy
copy number
risk factors
dna methylation
gene expression
genome wide