Endothelial NADPH oxidase 4 protects against angiotensin II-induced cardiac fibrosis and inflammation.

Minshu WangColin E MurdochAlison C BrewerAleksandar IveticPaul EvansAjay M ShahMin Zhang

Published in: ESC heart failure (2021)

A chronic increase in endothelial Nox4 stimulates physiological cardiac hypertrophy and protects against AngII-induced cardiac fibrosis by inhibiting EC activation and the recruitment of inflammatory cells.

Keyphrases

angiotensin ii
high glucose
diabetic rats
oxidative stress
endothelial cells
induced apoptosis
left ventricular
drug induced
angiotensin converting enzyme
vascular smooth muscle cells
heart failure
reactive oxygen species
atrial fibrillation