Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma.

Marjorie FlahautNicolas JauquierNadja ChevalierKatya NardouKatia Balmas BourloudJean-Marc JosephDavid BarrasChristian WidmannNicole GrossRaffaele RenellaAnnick Mühlethaler-Mottet

Published in: BMC cancer (2016)

Together our data uncover the participation of ALDH enzymatic activity in the aggressive properties and 4-hydroxycyclophosphamide resistance of NB, and show that the specific ALDH1A3 isoenzyme increases the aggressive capacities of a subset of NB cells.

Keyphrases

induced apoptosis
cell cycle arrest
physical activity
electronic health record
hydrogen peroxide
cell death
signaling pathway
deep learning
artificial intelligence