Renal tubular damage and worsening renal function in chronic heart failure: Clinical determinants and relation to prognosis (Bio-SHiFT study).

Milos BrankovicK Martijn AkkerhuisEwout J HoornNick van BovenJan C van den BergeAlina ConstantinescuJasper BrugtsJan van RamshorstTjeerd GermansHans HillegeEric BoersmaVictor UmansIsabella Kardys

Published in: Clinical cardiology (2020)

Slopes of tubular damage and WRF biomarkers had different clinical determinants. Both predicted clinical outcome, but this association was stronger for tubular injury. Prognostic effects of both appeared independent and additive.

Keyphrases

oxidative stress
high glucose