Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice.
Niran HadadDustin R MasserSreemathi LoganBenjamin WronowskiColleen A MangoldNicholas ClarkLaura OtaloraArchana UnnikrishnanMatthew M FordCory B GilesJonathan D WrenArlan RichardsonWilliam E SonntagDavid R StanfordWillard M FreemanPublished in: Epigenetics & chromatin (2016)
These findings clarify a long-standing misconception of the epigenomic response to aging and demonstrate the need for studies of base-specific methylation and hydroxymethylation with aging in both sexes.