MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET.
Ankit SrivastavaCristina TommasiDane SessionsAngela MahTomas BencomoJasmine M GarciaTiffany JiangMichael LeeJoseph Y ShenLek Wei SeowAudrey NguyenKimal RajapaksheCristian CoarfaKenneth Y TsaiVanessa Lopez-PajaresCarolyn S LeePublished in: Cancer research (2022)
Downregulation of RET mediated by MAB21L4-CacyBP interaction is required to induce epidermal differentiation and suppress carcinogenesis, suggesting RET inhibition as a potential therapeutic approach in squamous cell carcinoma.