MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET.

Ankit Srivastava Cristina Tommasi Dane Sessions Angela Mah Tomas Bencomo Jasmine M Garcia Tiffany JiangMichael LeeJoseph Y Shen Lek Wei Seow Audrey NguyenKimal RajapaksheCristian Coarfa Kenneth Y Tsai Vanessa Lopez-Pajares Carolyn S Lee

Published in: Cancer research (2022)

Downregulation of RET mediated by MAB21L4-CacyBP interaction is required to induce epidermal differentiation and suppress carcinogenesis, suggesting RET inhibition as a potential therapeutic approach in squamous cell carcinoma.

Keyphrases

squamous cell carcinoma
monoclonal antibody
lymph node metastasis
locally advanced
cell proliferation
signaling pathway
replacement therapy
wound healing
smoking cessation