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MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET.

Ankit SrivastavaCristina TommasiDane SessionsAngela MahTomas BencomoJasmine M GarciaTiffany JiangMichael LeeJoseph Y ShenLek Wei SeowAudrey NguyenKimal RajapaksheCristian CoarfaKenneth Y TsaiVanessa Lopez-PajaresCarolyn S Lee
Published in: Cancer research (2022)
Downregulation of RET mediated by MAB21L4-CacyBP interaction is required to induce epidermal differentiation and suppress carcinogenesis, suggesting RET inhibition as a potential therapeutic approach in squamous cell carcinoma.
Keyphrases
  • squamous cell carcinoma
  • monoclonal antibody
  • lymph node metastasis
  • locally advanced
  • cell proliferation
  • signaling pathway
  • replacement therapy
  • wound healing
  • smoking cessation