Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health.
Changli ZhangMadeleine D GordonKatherine M JosephMartha E Diaz-HernandezHicham DrissiSvenja Illien-JüngerPublished in: JOR spine (2023)
Our study indicates that NSC45586 was effective in promoting NP cell health, especially in males, suggesting that PHLPP plays a key role in NP cell homeostasis and that NSC45586 might be a potential drug candidate in treating IVD degeneration.