Exercise Ameliorates Emphysema Of Cigarette Smoke-Induced COPD In Mice Through The Exercise-Irisin-Nrf2 Axis.
Hiroaki KuboKazuhisa AsaiKazuya KojimaArata SugitaniYohkoh KyomotoAtsuko OkamotoKazuhiro YamadaNaoki IjiriTetsuya WatanabeKazuto HirataTomoya KawaguchiPublished in: International journal of chronic obstructive pulmonary disease (2019)
Irisin secreted from the muscle during exercise may exert protective effects against oxidative stress via Nrf2 and HO-1, and ameliorate emphysema of cigarette smoke-induced COPD. The exercise-irisin-Nrf2 axis may serve as a novel target for COPD treatment.
Keyphrases
- oxidative stress
- chronic obstructive pulmonary disease
- lung function
- diabetic rats
- high intensity
- physical activity
- resistance training
- high glucose
- cystic fibrosis
- dna damage
- type diabetes
- air pollution
- induced apoptosis
- skeletal muscle
- mouse model
- endothelial cells
- cell proliferation
- pulmonary fibrosis
- heat shock protein
- heat shock