The rs2341471-G/G genotype of activating transcription factor 6 (ATF6) is the risk factor of type 2 diabetes in subjects with obesity or overweight.
Elena KlyosovaIuliia AzarovaIrina PetrukhinaRamis KhabibulinAlexey V PolonikovPublished in: International journal of obesity (2005) (2024)
The present study revealed, for the first time, a strong association between the rs2341471-G/G ATF6 genotype and an increased risk of type 2 diabetes in people with obesity or overweight, regardless of known dietary risk factors. Further research is needed to support the potential of silencing the ATF6 gene as a means for the treatment and prevention of type 2 diabetes.
Keyphrases
- transcription factor
- weight loss
- risk factors
- weight gain
- insulin resistance
- genome wide identification
- endoplasmic reticulum stress
- metabolic syndrome
- type diabetes
- high fat diet induced
- dna binding
- body mass index
- physical activity
- signaling pathway
- genome wide
- single cell
- copy number
- adipose tissue
- climate change
- human health
- risk assessment
- replacement therapy
- smoking cessation