Filaggrin mutations increase allergic airway disease in childhood and adolescence through interactions with eczema and aeroallergen sensitization.
Adrian Kwok Wai ChanWilliam TerryHongmei ZhangWilfried KarmausSusan EwartJohn W HollowayGraham C RobertsRamesh KurukulaaratchySyed Hasan ArshadPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)
FLG-LOF mutations are a significant risk factor for later childhood asthma and rhinitis. However, the pathway to asthma is only through early childhood eczema while a direct effect was observed for childhood rhinitis.