Impact of Serum Cystatin C-Based Glomerular Filtration Rate Estimates on Drug Dose Selection in Hospitalized Patients.
Bradley J PetersAndrew D RuleKianoush B KashaniJohn C LieskeKristin C MaraRoss A DierkhisingErin Frazee BarretoPublished in: Pharmacotherapy (2018)
Significant discordance in drug doses was observed when the CKD-EPI equations were used in place of eClcr . When CysC was included in eGFR equations, recommended doses were often lower. Further study is needed to develop and test drug-specific dosing guidelines that incorporate alternate renal biomarkers and/or more contemporary eGFR equations.