Increased EZH2 function in regulatory T cells promotes their capacity to suppress autoimmunity by driving effector differentiation prior to activation.

Janneke G C PeetersStephanie SilveriaMerve OzdemirSrinivas RamachandranMichel DuPage

Published in: bioRxiv : the preprint server for biology (2024)

EZH2 function promotes effector differentiation of Treg cells.EZH2 function promotes Treg cell migration to organ tissues.EZH2 function in Treg cells improves remission from autoimmunity.EZH2 function poises naïve Treg cells to adopt a CD28-activated phenotype.

Keyphrases

regulatory t cells
induced apoptosis
cell cycle arrest
long non coding rna
dendritic cells
long noncoding rna
cell migration
gene expression
rheumatoid arthritis
cell death
immune response
cell proliferation
ulcerative colitis
pi k akt