Risk of Major Congenital Malformations Associated with the Use of Japanese Traditional (Kampo) Medicine Containing Ephedra During the First Trimester of Pregnancy.
Aoi NodaTaku ObaraFumiko MatsuzakiSatoko SuzukiRyutaro AritaMinoru OhsawaRyo ObaraKei MorishitaFumihiko UenoGenki ShinodaMasatsugu OruiKeiko MurakamiMami IshikuroAkiko KikuchiShin TakayamaTadashi IshiiHiroshi KawameShigeo KureShinichi KuriyamaPublished in: Drugs - real world outcomes (2024)
In this study, there was no statistically significant association between the use of Kampo medicines containing ephedra during the first trimester of pregnancy and the risk of MCMs. Although some point estimates of ORs exceeded 1.00, the absolute magnitude of any increased risks would be low.