Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides.
Elke M MuntjewerffKechun TangLisanne LutterGustaf ChristofferssonMara J T NicolasenHong GaoGajanan D KatkarSoumita DasMartin Ter BeestWei YingPradipta GhoshSahar El AidyBas OldenburgGeert van den BogaartSushil K MahataPublished in: Acta physiologica (Oxford, England) (2021)
The pro-hormone CgA regulates the intestinal paracellular permeability. CST is both necessary and sufficient to reduce permeability and primarily acts by antagonizing PST.
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