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Investigation of correlations between DNA methylation, suicidal behavior and aging.

Richie JeremianYi-An ChenVincenzo De LucaJohn B VincentJames L KennedyClement C ZaiJohn Strauss
Published in: Bipolar disorders (2017)
We report significant findings at three loci based on a methylome scan of participants with BD for an SB phenotype, and potentially altered molecular aging in suicide attempters. Despite the small sample size, our proof-of-concept study highlights the potential for epigenetic factors to be useful in understanding the molecular underpinnings of suicide with the ultimate aim of its prevention.
Keyphrases
  • dna methylation
  • genome wide
  • gene expression
  • depressive symptoms
  • single molecule
  • magnetic resonance imaging
  • risk assessment
  • human health
  • climate change