Small fragments of hyaluronan are increased in individuals with obesity and contribute to low-grade inflammation through TLR-mediated activation of innate immune cells.
Mònica RomoCristina López-VicarioNoelia Pérez-RomeroMireia CasullerasAna Isabel Martínez-PucholBelén SánchezRoger Flores-CostaJosé Alcaraz-QuilesMarta Duran-GüellAinitze IbarzábalJuan José EspertJoan ClàriaEsther TitosPublished in: International journal of obesity (2005) (2022)
Circulating LMW HA molecules are elevated in obesity and may play an important role in triggering low-grade inflammation and the development of metabolic complications.
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