Small fragments of hyaluronan are increased in individuals with obesity and contribute to low-grade inflammation through TLR-mediated activation of innate immune cells.
Mònica RomoCristina López-VicarioNoelia Pérez-RomeroMireia CasullerasAna Isabel Martínez-PucholBelén SánchezRoger Flores-CostaJosé Alcaraz-QuilesMarta Duran-GüellAinitze IbarzábalJuan José EspertJoan ClàriaEsther TitosPublished in: International journal of obesity (2005) (2022)
Circulating LMW HA molecules are elevated in obesity and may play an important role in triggering low-grade inflammation and the development of metabolic complications.
Keyphrases
- low grade
- innate immune
- high grade
- insulin resistance
- oxidative stress
- metabolic syndrome
- weight loss
- induced apoptosis
- high fat diet induced
- type diabetes
- weight gain
- cell cycle arrest
- toll like receptor
- immune response
- risk factors
- adipose tissue
- skeletal muscle
- endoplasmic reticulum stress
- cell death
- signaling pathway
- physical activity