Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy.
Mária LódiViktor BánhegyiBeáta BódiAlexandra GyöngyösiÁrpád KovácsAnita ÁrokszállásiNazha HamdaniMiklós FagyasIstván ÉdesZoltán CsanádiIstván CzurigaZoltán KisvárdayIstván LekliPéter BaiAttila TóthZoltán PappDaniel CzurigaPublished in: Journal of translational medicine (2020)
Primary prophylaxis with cardioprotective agents like BB or ACEI has a key role in the prevention of DOX-induced cardiotoxicity in healthy rats. Future human studies are necessary to implement this finding in the clinical management of oncological patients free of cardiovascular risk factors.
Keyphrases
- cardiovascular risk factors
- high glucose
- endothelial cells
- end stage renal disease
- diabetic rats
- drug induced
- ejection fraction
- newly diagnosed
- chronic kidney disease
- cardiovascular disease
- heart failure
- metabolic syndrome
- type diabetes
- drug delivery
- prognostic factors
- prostate cancer
- peritoneal dialysis
- oxidative stress
- rectal cancer
- cancer therapy
- radical prostatectomy