Mitigation of aircraft noise-induced vascular dysfunction and oxidative stress by exercise, fasting, and pharmacological α1AMPK activation: molecular proof of a protective key role of endothelial α1AMPK against environmental noise exposure.
Miroslava KvandováSanela RajlicPaul StammIsabella SchmalDominika MihalikováMarin KunticMaría Teresa Bayo JiménezOmar HahadMarta KollárováHenning UbbensLea StrohmKatie FrenisGeorg Daniel DuerrMarc ForetzBenoit ViolletYue RuanSubao JiangQi TangHartmut KleinertSteffen RappAdrian GerickeEberhard SchulzMatthias OelzeJohn F KeaneyAndreas DaiberSwenja Kröller-SchönThomas JansenThomas MunzelPublished in: European journal of preventive cardiology (2023)
Our results demonstrate that endothelial-specific α1AMPK activation by pharmacological stimulation, exercise, and intermittent fasting effectively mitigates noise-induced cardiovascular damage. Future population-based studies need to clinically prove the concept of exercise/fasting-mediated mitigation of transportation noise-associated disease.
Keyphrases
- oxidative stress
- high intensity
- diabetic rats
- air pollution
- blood glucose
- high glucose
- skeletal muscle
- insulin resistance
- endothelial cells
- physical activity
- climate change
- resistance training
- protein kinase
- dna damage
- type diabetes
- risk assessment
- radiation therapy
- metabolic syndrome
- induced apoptosis
- blood pressure
- body composition
- radiation induced
- weight loss