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Feasibility of in vivo CAR T cells tracking using streptavidin-biotin-paired positron emission tomography.

Donghui PanYan WangNan XuYuping XuXinyu WangLizhen WangJunjie YanLei YuLiyan MiaoGuangji WangMin Yang
Published in: European journal of nuclear medicine and molecular imaging (2022)
SA-CD19-CAR T cells were constructed successfully without disturbing the antitumor functions of the cells. The proliferation of the CAR T cells in solid tumors could be early detected by [<sup>68</sup> Ga]Ga-DOTA-biotin PET imaging.
Keyphrases
  • pet imaging
  • pet ct
  • positron emission tomography
  • induced apoptosis
  • computed tomography
  • cell cycle arrest
  • signaling pathway
  • endoplasmic reticulum stress
  • oxidative stress
  • wastewater treatment
  • cell death
  • nk cells