TMEM106B Effect on cognition in Parkinson disease and frontotemporal dementia.

Thomas Francis TropeaJordan MakMichael H GuoSharon X XieEunran SuhJacqueline RickAndrew SiderowfDaniel WeintraubMurray GrossmanDavid IrwinDavid A WolkJohn Q TrojanowskiVivianna Van DeerlinAlice S Chen-Plotkin

Published in: Annals of neurology (2020)

Irrespective of cognitive instrument or cohort assessed, TMEM106B acts as a genetic modifier for cognitive trajectory in PD. Our results implicate lysosomal dysfunction in the pathogenesis of cognitive decline in 2 different proteinopathies. ANN NEUROL 2019;85:801-811.

Keyphrases

cognitive decline
parkinson disease
mild cognitive impairment
deep brain stimulation
oxidative stress
genome wide
copy number
white matter
patient reported outcomes