Neuroblastoma Molecular Risk-Stratification of DNA Copy Number and ALK Genotyping via Cell-Free Circulating Tumor DNA Profiling.

Smadar Kahana-EdwinLucy E CainGeoffrey McCowageArtur DarmanianDale WrightAnna MullinsFederica SalettaJonathan Karpelowsky

Published in: Cancers (2021)

These results demonstrate the feasibility of ctDNA profiling for molecular risk-stratification, and treatment monitoring in a clinically relevant time frame and the potential to reduce fresh tissue requirements currently embedded in the management of neuroblastoma.

Keyphrases

circulating tumor
cell free
copy number
mitochondrial dna
genome wide
circulating tumor cells
single cell
dna methylation
single molecule
advanced non small cell lung cancer
climate change
replacement therapy
tyrosine kinase