The association between non-breast and ovary cancers and BRCA mutation in first- and second-degree relatives of high-risk breast cancer patients: a large-scale study of Koreans.

Hakyoung KimDoo Ho ChoiWon ParkYoung-Hyuck ImJin Seok AhnYeon Hee ParkSeok Jin NamSeok Won KimJeong Eon LeeJong Hwan YuSe Kyung LeeBoo Yeon Jung

Published in: Hereditary cancer in clinical practice (2019)

We confirmed that BRCA mutation was associated with having multiple risk factors and an increased prevalence of non-breast and ovary cancers in first- and second-degree relatives of high-risk breast cancer patients. Due to the possibility of inherited cancer risk, genetic counseling with options for risk assessment and management should be provided to both patients and families of BRCA mutation carriers.

Keyphrases

risk factors
risk assessment
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
breast cancer risk
human health
gene expression
climate change
copy number
smoking cessation