Tgfβ1-Cthrc1 Signaling Plays an Important Role in the Short-Term Reparative Response to Heart Valve Endothelial Injury.
Emily M NordquistPunashi DuttaKarthik M KodigepalliCarol MatternMichael R McDermottAaron J TraskStephanie LaHayeVolkhard LindnerJoy LincolnPublished in: Arteriosclerosis, thrombosis, and vascular biology (2021)
Data from this study suggests that the healthy valve has the capacity to respond to mild endothelial injury, which in short term has beneficial effects on restoring endothelial barrier function through acute activation of the Tgfβ1-Cthrc1 signaling axis and cell proliferation.
Keyphrases
- endothelial cells
- cell proliferation
- aortic valve
- mitral valve
- transforming growth factor
- liver failure
- heart failure
- aortic stenosis
- cell cycle
- electronic health record
- respiratory failure
- atrial fibrillation
- big data
- epithelial mesenchymal transition
- machine learning
- left ventricular
- signaling pathway
- ejection fraction
- artificial intelligence