Chiral MOF derived wearable logic sensor for intuitive discrimination of physiologically active enantiomer.

Chiral sensors have attracted growing interests due to their potential application in health monitoring. However, rational design of wearable logic chiral sensors remains a great challenge. In this work, a dual responsive chiral sensor RT@CDMOF is prepared through in situ self-assembly of chiral γ-cyclodextrin metal-organic framework (CDMOF), rhodamine 6G hydrazide (RGH) and tetracyanovinylindane (TCN). The embedded RGH and TCN inherit the chirality of host CDMOF, producing dual stimuli-responsive changes both in fluorescence and reflectance. RT@CDMOF is explored as a dual channel sensor for chiral discrimination of lactate enantiomers visually. Time-dependent in situ FTIR, QCM and DFT calculations reveal the chiral H-bonding recognition process, and the subsequent carboxylate dissociation is confirmed by EIS, solid-state and solution 1H NMR. A flexible membrane sensor is successfully fabricated based on RT@CDMOF for wearable health monitoring. On-body practical evaluation confirms the promising potential of fabricated membrane sensor in point-of-care health monitoring by indexing the exercise intensity. Based on the chiral sensing features, a chiral IMPLICATION logic unit could be successfully achieved, demonstrating the promising potential of RT@CDMOF in design and assembly of novel smart devices. This work may open a new avenue to the rational design of logic chiral sensors for wearable health monitoring applications. This article is protected by copyright. All rights reserved.