Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration.
Ayako SuzukiHans TillmannJames WilliamsRonald G HauserJulie FrundMizuki SuzukiFred W PriorGuruprasad Padur AithalMaría Isabel LucenaRaúl Jesús AndradeWeida TongChristine M HuntPublished in: Drug safety (2022)
This framework identifies unexplained acute liver injury following drug exposure in large electronic health record datasets. After validating in other systems, this framework can aid in deducing drug-induced liver injury in the general patient population and regulatory decision making to promote drug safety and public health.
Keyphrases
- drug induced
- liver injury
- public health
- electronic health record
- adverse drug
- end stage renal disease
- decision making
- healthcare
- ejection fraction
- chronic kidney disease
- clinical decision support
- peritoneal dialysis
- case report
- prognostic factors
- liver failure
- transcription factor
- emergency department
- gene expression
- type diabetes
- genome wide
- rna seq
- risk assessment
- patient reported outcomes
- social media
- skeletal muscle
- insulin resistance
- single cell
- human health
- extracorporeal membrane oxygenation