EAAT1-dependent slc1a3 Transcriptional Control depends on the Substrate Translocation Process.
Dinorah Hernández-MelchorLeticia Ramírez-MartínezLuis CidCecilia Palafox-GómezEsther López-BayghenArturo OrtegaPublished in: ASN neuro (2022)
EAAT1/GLAST down-regulates its expression and function at the transcriptional level by activating a signaling pathway that includes PI3K, PKC and NF-κB, favoring the notion of an activity-dependent fine-tuning of glutamate recycling and its synaptic transactions through glial cells.
Keyphrases
- signaling pathway
- induced apoptosis
- pi k akt
- cell cycle arrest
- gene expression
- transcription factor
- epithelial mesenchymal transition
- oxidative stress
- neuropathic pain
- air pollution
- heat shock
- endoplasmic reticulum stress
- lps induced
- binding protein
- inflammatory response
- spinal cord
- nuclear factor
- amino acid
- protein kinase