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Application of the matched nested case-control design to the secondary analysis of trial data.

Christopher PartlettNigel J HallAlison LeafEdmund JuszczakLouise Linsell
Published in: BMC medical research methodology (2020)
A matched nested case-control study can be used to identify credible associations in a secondary analysis of clinical trial data where the exposure of interest was not randomised, and has several advantages over a standard case-control design. This method offers the potential to make reliable inferences in scenarios where it would be unethical or impractical to perform a randomised clinical trial.
Keyphrases
  • case control
  • clinical trial
  • phase ii
  • open label
  • study protocol
  • phase iii
  • double blind
  • electronic health record
  • big data
  • climate change
  • placebo controlled
  • data analysis
  • human health
  • risk assessment
  • deep learning