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Early-life undernutrition induces enhancer RNA remodeling in mice liver.

Yinyu WangYiting MaoYiran ZhaoXianfu YiGuolian DingChuanjin YuJianzhong ShengXinmei LiuYicong MengHe-Feng Huang
Published in: Epigenetics & chromatin (2021)
Our study reveals novel insights into mechanisms of metabolic dysfunction. Enhancer activity in early life acts on metabolism-associated genes, leading to the increased susceptibility of metabolic disorders.
Keyphrases
  • early life
  • transcription factor
  • binding protein
  • oxidative stress
  • genome wide
  • type diabetes
  • dna methylation
  • adipose tissue
  • skeletal muscle
  • metabolic syndrome
  • bioinformatics analysis
  • nucleic acid