Engineering Hyaluronic Acid Microneedles Loaded with Mn 2+ and Temozolomide for Topical Precision Therapy of Melanoma.
Yechun JiangYu JinChengcheng FengYayun WuWeinan ZhangLiang XiaoZhaoyou ChuBenjin ChenYan MaHai-Sheng QianLingling XuPublished in: Advanced healthcare materials (2023)
Topical therapy has received worldwide attention for in situ tumors owing to its higher efficacy of drug delivery. Herein, this work reports a dissolvable multifunctional hyaluronic acid microneedles (HMNs) patch coloaded with temozolomide (TMZ) and MnCl 2 (TMZ/MnCl 2 @HMN) for chemoimmunotherapy of melanoma. HMNs can ensure the stability of TMZ over time, and exhibit fewer side effects with a localized release way. In particular, TMZ not only promotes dendritic cell maturation by triggering immunogenic cell death in tumor cells, but also induces DNA damage that can further enhance the Mn 2+ -activated cGAS-STING (stimulator of interferon genes pathway). As a result, the TMZ/MnCl 2 @HMN multifunctional platform significantly inhibits lung metastases for melanoma, providing a practical strategy for precision therapy of melanoma.
Keyphrases
- hyaluronic acid
- drug delivery
- dendritic cells
- dna damage
- cell death
- cancer therapy
- skin cancer
- oxidative stress
- gene expression
- emergency department
- stem cells
- dna repair
- working memory
- genome wide
- wound healing
- high throughput
- newly diagnosed
- immune response
- cell proliferation
- transcription factor
- bone marrow
- signaling pathway
- drug release
- cell cycle arrest
- ionic liquid
- smoking cessation