Immunogenic hotspots in the spacer domain of ADAMTS13 in immune-mediated thrombotic thrombocytopenic purpura.

Leydi Carolina Velásquez PereiraElien RooseNuno A G GraçaGyörgy SinkovitsKadri KangroBérangère S JolyEdwige TellierGilles KaplanskiTanja FalterCharis Von AuerHeidi RossmannHendrik B FeysMarienn RetiZoltán ProhászkaBernhard LämmleJan VoorbergPaul CoppoAgnès VeyradierSimon F De MeyerAndres MännikKaren Vanhoorelbeke

Published in: Journal of thrombosis and haemostasis : JTH (2020)

We identified three hotspot regions (amino acid regions 588-592, 602-610, and 657-666) in the spacer domain of ADAMTS13 that are targeted by anti-spacer autoantibodies found in a large cohort of iTTP patients.

Keyphrases

end stage renal disease
amino acid
ejection fraction
newly diagnosed
chronic kidney disease
systemic lupus erythematosus
peritoneal dialysis
prognostic factors
cancer therapy
drug delivery