Bi-directional regulation of AIMP2 and its splice variant on PARP-1-dependent neuronal cell death; Therapeutic implication for Parkinson's disease.

Min Hak LeeKi-Hwan UmSeok Won LeeYe Ji SunDa-Hye GuYoung Ok JoSung Hyun KimWongi SeolHyorin HwangKyunghwa BaekJin Woo Choi

Published in: Acta neuropathologica communications (2024)

AIMP2 and DX2 are proposed to engage in bidirectional regulation of parthanatos. They physically interact with PARP-1. Notably, DX2's cell survival properties manifest exclusively in the context of abnormal AIMP2 accumulation, devoid of any tumorigenic effects. This suggests that DX2 could represent a distinctive therapeutic target for addressing Parkinson's disease in patients.

Keyphrases

cell death
end stage renal disease
dna damage
ejection fraction
dna repair
newly diagnosed
chronic kidney disease
prognostic factors
oxidative stress
cell proliferation
signaling pathway
patient reported