Developing biomaterials to mediate the spatial distribution of integrins.

Innovation in material design to regulate cell behavior and function is one of the primary tasks in materials science. Integrins, a family of cell surface-adhesion receptors that mechanically connect the extracellular matrix (ECM) to the intracellular cytoskeleton, have long served as primary targets for the design of biomaterials because their activity is not only critical to a wide range of cell and tissue functions but also subject to very tight and complex regulations from the outside environment. To review the recent progress of material innovations targeting the spatial distribution of integrins, we first introduce the interaction mechanisms between cells and the ECM by highlighting integrin-based cell adhesions, describing how integrins respond to environmental stimuli, including variations in ligand presentation, mechanical cues, and topographical variations. Then, we overview the current development of soft materials in guiding cell behaviors and functions via spatial regulation of integrins. Finally, we discuss the current limitations of these technologies and the advances that may be achieved in the future. Undoubtedly, synthetic soft materials that mediate the spatial distribution of integrins play an important role in biomaterial innovations for advancing biomedical applications and addressing fundamental biological questions.