Increased oxidative stress alters nucleosides metabolite levels in sickle cell anemia.

Lívia Gelain CastilhosJuliana Sorraila de OliveiraStephen Adeniyi AdefeghaLuana Pereira MagniPedro Henrique DoleskiFatima Husein AbdallaCínthia Melazzo de AndradeDaniela Bitencourt Rosa Leal

Published in: Redox report : communications in free radical research (2017)

The altered parameters in SCA patients suggest that the generation and impairment of oxidative stress in this disease as well as antioxidant markers are contributory factors towards cellular redox homeostasis and alteration of purine metabolites.

Keyphrases

oxidative stress
end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
dna damage
ischemia reperfusion injury
prognostic factors
diabetic rats
ms ms
patient reported outcomes
iron deficiency
heat stress