SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.

Yanlu XiongLei WangShan WangMingxing WangJinbo ZhaoZhipei ZhangXiaofei LiLintao JiaYong Han

Published in: Journal of cancer research and clinical oncology (2017)

We have identified a novel mechanism by which P53 was inactivated via SIRT3 in PTEN-deficient cells. This may shed light on the mechanisms underlying the malignancy of PTEN-deficient NSCLC.

Keyphrases

pi k akt
cell cycle arrest
cell proliferation
induced apoptosis
oxidative stress
signaling pathway
small cell lung cancer
ischemia reperfusion injury
advanced non small cell lung cancer
cell death
endoplasmic reticulum stress